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[Correspondence] Strengthening the reporting of stillbirths globally – Authors' reply

Sa, 08/01/2022 - 00:00
We appreciate the comments by Olga Joos and colleagues, in response to our Article,1 on prioritising stillbirth reporting and registration within civil registration and vital statistics system strengthening efforts. Improving data collection and data quality in low-income and middle-income countries (LMICs) is key since far too many of these countries have very scarce or no quality data on stillbirths. Integrating stillbirths in the vital registration process will allow us to produce better and more timely estimates of the risk of stillbirth and analyse inequities at the subnational level.

[Department of Error] Department of Error

Sa, 08/01/2022 - 00:00
Abdool Karim SS, Abdool Karim Q. Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic. Lancet 2021; 398: 2126–28 — In this Comment, reference 5 has been replaced with the correct reference. This correction has been made to the online version as of Jan 6, 2022.

[Clinical Picture] Pectoralis minor muscle causes venous thoracic outlet syndrome: visualised using venography

Sa, 08/01/2022 - 00:00
A 50-year-old man attended our specialised clinic reporting swelling, paraesthesia, discolouration, and fatigue in both arms while doing physical activity. The patient said the problem was particularly bad when lifting objects above his shoulders; his right side was worse than his left.

[Editorial] The state of science and society in 2022

Sa, 01/01/2022 - 00:00
As 2022 begins, and the third year of the pandemic continues to put pressure on both the scientific community and the public, it is worth considering the state of science and society. The main headline from Wellcome's Global Monitor 2020: Covid-19 survey was that global public trust in science and scientists grew during the pandemic. The largest of its kind, the survey covered 119 000 people in 113 countries, and seems to suggest that, after a year of heightened exposure to scientists, and with the first COVID-19 vaccines hailed as a scientific triumph, the value of science might not have eroded as badly as the common narrative—of rising infodemics, vaccine hesitancy, protests against public health measures, and populist politicians—implies.

[Comment] Offline: The origin story—towards a final resolution?

Sa, 01/01/2022 - 00:00
WHO has been a particular casualty in the dispute about the origins of SARS-CoV-2. Former US President Donald Trump's verbal attacks and his decision to defund the agency drew blood in Geneva—and the wounds are still visible. The allegation that WHO shared responsibility for the pandemic by adopting a policy of appeasement towards China has proven impossible to refute. As a member-state organisation, WHO's staff are constitutionally bound to heed the instructions of the governments they serve. Only former Norwegian Prime Minister Gro Harlem Brundtland had the courage to defy countries when she was WHO Director-General during the first SARS outbreak in 2003.

[World Report] Médecins Sans Frontières: 50 years of bearing witness

Sa, 01/01/2022 - 00:00
MSF was founded half a century ago. It has transformed humanitarianism and global health. But it is facing new challenges. Udani Samarasekera reports.

[Perspectives] Does it really matter if you win or lose the genetic lottery?

Sa, 01/01/2022 - 00:00
Kathryn Paige Harden, Professor of Psychology who leads the Developmental Behavior Genetics lab at the University of Texas at Austin, USA, is considered by many in her field as an up and coming superstar. Her book, The Genetic Lottery: Why DNA Matters for Social Equality, proposes that an individual's genetic composition, specifically related to their capacity to succeed at education, has an important role in determining their social outcomes. Harden examines the role that an individual's genetic predisposition may have in contributing to their position in society.

[Perspectives] Sivaramakrishna Iyer Padmavati: trailblazing cardiologist in India

Sa, 01/01/2022 - 00:00
The first woman from India to qualify in cardiology, Sivaramakrishna Iyer Padmavati (1917–2020), helped to set up the All India Heart Foundation and was a founder of its National Heart Institute (NHI) in New Delhi. Fellow cardiologists in her home country dubbed her the “godmother of cardiology”, and her example persuaded other pioneering women doctors in India that they could specialise outside the traditional career path of obstetrics and paediatrics.

[Obituary] Elihu Harris Estey

Sa, 01/01/2022 - 00:00
Authority on acute myeloid leukaemia. He was born in New York, NY, USA, on July 15, 1946, and died of a probable myocardial infarction in Seattle, WA, USA, on Oct 8, 2021, aged 75 years.

[Correspondence] Caution required with use of ritonavir-boosted PF-07321332 in COVID-19 management

Sa, 01/01/2022 - 00:00
We read with interest the news that the UK Government has announced deals to procure the oral antivirals for SARS-CoV-2, molnupiravir (Lagevrio, Merck [Branchburg, NJ, USA]) and ritonavir in combination with PF-07321332 (Paxlovid, Pfizer [New York, NY, USA]).1 Although we welcome further partnership between the government and pharmaceutical industry in the provision of effective agents to manage the COVID-19 pandemic, we urge caution with the widescale use of ritonavir, given its propensity for causing clinically significant drug–drug interactions with commonly prescribed and over-the-counter medications.

[Correspondence] COVID-19 ARDS: getting ventilation right

Sa, 01/01/2022 - 00:00
We read with special interest the Article by Ryan Barbaro and colleagues,1 describing the evolving outcomes of patients with COVID-19 who required extracorporeal membrane oxygenation (ECMO) during 2020. We were sad to corroborate the same increased mortality we had observed in our own patients. However, we wish to clarify two key aspects that we hope will supplement the conclusions of this important Article.

[Correspondence] COVID-19 ARDS: getting ventilation right – Authors' reply

Sa, 01/01/2022 - 00:00
We thank Xosé Pérez-Fernández and colleagues for their thoughtful Correspondence regarding our study of extracorporeal membrane oxygenation (ECMO) in COVID-19.1 We agree that our study does not provide evidence that forms of non-invasive ventilation (NIV), such as high-flow nasal cannula and mask or helmet ventilation, might be deleterious compared with other strategies. Our observational study was not designed to make causal inferences regarding the potential superiority of ECMO or any pre-ECMO support strategy.

[Correspondence] Brazilian science under continuous attack

Sa, 01/01/2022 - 00:00
Despite the resistance of Brazilian scientists, science in Brazil has been undermined by measures implemented by the federal government in the past 3 years, such as increasing budget cuts, attacks on the autonomy of universities, and a general policy of denial of science. A recent budget cut of US$110 million to the Ministry of Science Technology and Innovations budget, in addition to the withholding of $490 million from the National Scientific and Technological Development Fund, not only represents an enormous impediment to conducting research at universities and research institutes, but also jeopardises the future scientific development of a country.

[Correspondence] New INN nomenclature for monoclonal antibodies

Sa, 01/01/2022 - 00:00
Monoclonal antibodies (mAbs) are the largest class of biological products in clinical use. They comprise a large variety of different structures, from small fragments to intact, modified, or unmodified immunoglobulins, all of which contain an antigen binding domain.

[Clinical Picture] HTLV-1 uveitis and Graves' disease presenting with sudden onset of blurred vision

Sa, 01/01/2022 - 00:00
A 25-year-old woman presented to our hospital with sudden onset of blurred vision in her right eye. The patient had a history of Graves' disease and had started methimazole 20 mg daily 2 months earlier: investigations at that time had found her free tri-iodothyronine concentration at 13·60 pg/mL (normal 1·71–3·71), free thyroxine 2·93 ng/dL (normal 0·70–1·48), thyroid-stimulating hormone (TSH) of 0·01 μU/mL (normal 0·35–4·94), and TSH-receptor antibody of 11·4 IU/L (normal 0·0–1·9).

[Comment] Mandatory COVID-19 vaccination and human rights

Ve, 24/12/2021 - 00:30
On Dec 9, 2021 the Austrian Government laid a bill before parliament that would impose a mandatory COVID-19 vaccination requirement for all its residents.1 This move followed the Greek Prime Minister's announcement to impose fines on residents aged 60 years and older who do not take up COVID-19 vaccination.2 Many other nations are contemplating similar mandates or have adopted mandates in certain workplace settings, such as Australia, Brazil, Canada, France, Indonesia, Italy, and the UK.3 Some people resist vaccine mandates on pragmatic grounds, for example, that such mandates could decrease health-care staffing levels or morale.

[Comment] Efficacy of an adenovirus type 5 vectored SARS-CoV-2 vaccine

Ve, 24/12/2021 - 00:30
Despite remarkable accomplishments in SARS-CoV-2 vaccine development and production, there are still large regions of the world where access to vaccines remains limited.1 In some areas of the world vaccine hesitancy is also an obstacle to achieving high vaccination coverage.2 In addition to these challenges, there is waning immunity from the SARS-CoV-2 vaccines and a continued emergence of variants capable of different degrees of immune evasion. Thus, there is a clear and urgent need for the continued development, testing, and use of additional vaccines.

[Comment] The health and wellbeing of Indigenous adolescents: a global collective for an equitable and sustainable future

Me, 22/12/2021 - 00:30
Indigenous peoples, comprising almost 500 million individuals from across 90 countries, hold the longest continuous cultures on this planet.1 Despite the negative impacts of colonisation, Indigenous peoples have survived and continue to nurture and live their Indigenous knowledges, languages, and cultural practices. Indigenous peoples have made substantial contributions to global health. For example, the parts of the health sector controlled by the Indigenous community in Australia helped shape the principles of primary health care in the pivotal Alma-Ata Declaration in 1978,2 which is a foundation of universal health coverage.

[Comment] Oral health problems are global and need to be addressed in the USA

Ma, 21/12/2021 - 16:00
The COVID-19 pandemic has shown unequivocally that science, innovation, collaboration, and leadership are important for the health and wellbeing of all people. In the USA, long-standing systemic health and social inequities have placed racial and minority ethnic groups, those living in poverty or with special health-care needs, and older people at increased risk of becoming infected, being hospitalised, and dying from COVID-19.1 A new report from the US National Institutes of Health (NIH), Oral Health in America: Advances and Challenges,2 to which we contributed, was published on Dec 21, 2021.