Trombofilia ed estroprogestinici: ora c’è consenso

Thrombophilia and oral contraception
Thrombophilia (a condition that increases the tendency to develop blood clots) may be inherited or acquired, due to lifestyle or medical and surgical conditions. The most common genetic condition that can cause thrombophilia are factor V Leiden mutation and prothrombin mutation. Other inherited causes include protein C, protein S, or antithrombin III deficiencies.
During oral contraception, women with thrombophilic defects can be considered at higher risk of developing thrombotic complications, even though the absolute risk is low. While predictive value of a family history of VTE is uncertain, an overall population screening of genetic defects that lead to increased risk of thrombosis is, however, not recommended. A recent Consensus Conference established that a screening would be not cost-effective and that physicians must weigh risks and benefits: women who don’t use oral contraception may be not protected not only against unwanted pregnancies, but also against menstrual symptoms and some neoplastic diseases.
oral contraceptives; thrombophilia