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Copyright Il Sole 24 ORE S.p.A. Tutti i diritti sono riservati
Copyright Il Sole 24 ORE S.p.A. Tutti i diritti sono riservati
New England Journal of Medicine
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Aggiornato: 1 anno 28 settimane fa
Aprepitant for Erlotinib-Induced Pruritus
To the Editor: Aprepitant is the first commercially available drug of a new class of neurokinin-1-receptor antagonists for treating chemotherapy-induced ...
Categorie: Riviste scientifiche
Orotracheal Intubation
Orotracheal Intubation . In the second paragraph of the Equipment section (page e15), the second sentence should have read, "The appropriate tube size for use in children can be determined ...
Categorie: Riviste scientifiche
Another Selective Estrogen-Receptor Modulator for Osteoporosis
Another Selective Estrogen-Receptor Modulator for Osteoporosis . In the fifth paragraph (page 752), the first sentence should have read, "In the PEARL study, lasofoxifene was associated with a reduction of ...
Categorie: Riviste scientifiche
CPAP and Low Oxygen Saturation for Very Preterm Babies?
CPAP and Low Oxygen Saturation for Very Preterm Babies? . In the fourth paragraph (page 2025), the fourth sentence should have read, "In the COIN trial, pneumothorax occurred in 9.1% ...
Categorie: Riviste scientifiche
CME: Effectiveness of Sensor-Augmented Insulin-Pump Therapy in Type 1 Diabetes
(No abstract is available for this citation)
Categorie: Riviste scientifiche
CME: A Randomized Trial of Treatment for Acute Anterior Cruciate Ligament Tears
(No abstract is available for this citation)
Categorie: Riviste scientifiche
CME: Functional Hypothalamic Amenorrhea
(No abstract is available for this citation)
Categorie: Riviste scientifiche
The Path to Personalized Medicine
Major investments in basic science have created an opportunity for significant progress in clinical medicine. Researchers have discovered hundreds of genes that harbor variations contributing to human illness, identified genetic ...
Categorie: Riviste scientifiche
The ACA's New Weapons against Health Care Fraud
Marshaling expanded financial resources, aggressive new legal authority, and rare bipartisan solidarity, the Obama administration is accelerating federal efforts to fight health care fraud, waste, and abuse that cost taxpayers ...
Categorie: Riviste scientifiche
Cancer Clinical Trials -- A Chronic but Curable Crisis
In April, the Institute of Medicine (IOM) released a comprehensive review of the clinical trials program of the National Cancer Institute (NCI), in which it concluded that "the system for ...
Categorie: Riviste scientifiche
Effectiveness of Sensor-Augmented Insulin-Pump Therapy in Type 1 Diabetes
In this randomized trial, sensor-augmented pump therapy was compared with a regimen of multiple daily insulin injections in adults and children with inadequately controlled type 1 diabetes. Pump therapy was associated with a significant improvement in glycated hemoglobin levels, as compared with injection therapy.
Categorie: Riviste scientifiche
Genetic Ancestry in Lung-Function Predictions
Self-reported race or ethnic group is used to determine reference standards in the prediction of lung function. This study suggests that the inclusion of genetic measures of African ancestry may improve predictions of lung function. Studies investigating the clinical usefulness of genetic markers of ancestry in determining the severity of pulmonary disease seem to be warranted.
Categorie: Riviste scientifiche
A Randomized Trial of Treatment for Acute Anterior Cruciate Ligament Tears
In this randomized, controlled trial of young, active adults with an acute anterior cruciate ligament (ACL) injury, rehabilitation plus early ACL reconstruction was not superior to rehabilitation plus optional delayed ACL reconstruction with respect to pain, symptoms, knee function, and knee-related quality of life, and it resulted in significantly more knee reconstructions.
Categorie: Riviste scientifiche
Molecular Architecture of the Goodpasture Autoantigen in Anti-GBM Nephritis
This study compared the conformation of the antibody epitopes in Goodpasture's disease and Alport's post-transplantation nephritis in search of the pathogenesis of anti-basement membrane glomerulonephritis. The authors report evidence that the initiation of such disease depends on the conformation involving perturbation of the quaternary structure of basement-membrane collagen, eliciting an autoimmune response.
Categorie: Riviste scientifiche
Efficacy of Gene Therapy for X-Linked Severe Combined Immunodeficiency
In a long-term (up to 11 years) follow-up of nine patients with X-linked severe combined immunodeficiency treated with retroviral insertion of a normal common {gamma}-chain gene into hematopoietic progenitors, seven had durable T-cell reconstitution and long-term survival. B-cell immunity was not corrected. Acute leukemia developed in four patients. In patients without a matched marrow donor, gene therapy may be an option but is associated with serious risks.
Categorie: Riviste scientifiche
Functional Hypothalamic Amenorrhea
A 16-year-old girl presents for evaluation of secondary amenorrhea. Her menarche was at the age of 12 years. Her last menstrual period was 6 months ago. She has lost 2.3 kg (5 lb) over the past 3 months and reports a 2-week history of unilateral foot pain. She typically runs 10 km (6 mi) per day, at least five times per week. Her body-mass index is 19. How should her case be evaluated and managed?
Categorie: Riviste scientifiche
Clinical Evaluation of the Knee
Figure
Knee problems are one of the most common musculoskeletal symptoms evaluated by the primary care physician. This video shows how to perform a comprehensive examination of the knee.
Categorie: Riviste scientifiche
Chloroquine-Induced Hair Hypopigmentation
A 16-year-old, blonde-haired patient was evaluated for a new band of lighter-colored hair located approximately 3 cm from the scalp. The patient first noted the change in hair color 1 ...
Categorie: Riviste scientifiche
Congenital Cholesteatoma of the Middle Ear
A 9-year-old boy was referred to an otolaryngologist for subjective right-sided hearing loss. A hearing test revealed mild conductive hearing loss at low and middle frequencies. Otoendoscopy showed a mass ...
Categorie: Riviste scientifiche
Case 22-2010 -- An 87-Year-Old Woman with Dementia and a Seizure
An 87-year-old woman with a history of dementia was admitted to this hospital because of a seizure. A diagnosis of possible Alzheimer's disease had been made 4 years earlier; at baseline, she recognized only her husband and children. On examination, she was unresponsive. Magnetic resonance imaging scans of the brain revealed T2-weighted hyperintensities in the white matter involving both cerebral hemispheres, as well as innumerable small foci of susceptibility-weighted artifact at the cortical-subcortical junction. Despite a temporary improvement after treatment, she died of pneumonia a few days later. An autopsy was performed.
Categorie: Riviste scientifiche