Riviste scientifiche

Don't Miss: Netflix's Away sees Hilary Swank on perilous Mars mission

New Scientist - Me, 02/09/2020 - 20:00
New Scientist's weekly round-up of the best books, films, TV series, games and more that you shouldn't miss

Inside the ISS: Astronauts tell their amazing tales of living in space

New Scientist - Me, 02/09/2020 - 20:00
Real-life accounts of International Space Station crew members Samantha Cristoforetti and Terry Virts capture the extraordinarily ordinary life of an astronaut

Joe Henrich interview: Psychology must look beyond Western cultures

New Scientist - Me, 02/09/2020 - 20:00
Most psychology studies involve people living in Western, Educated, Industrialised, Rich and Democratic societies. But the peculiarities of WEIRD thinking are far from universal

A lot of veg is 'toxic' but that doesn't mean you shouldn't eat it

New Scientist - Me, 02/09/2020 - 20:00
There are claims online that most of the fruit and veg we eat is toxic. Though there is some truth to this, it doesn't mean you should stop eating your greens, writes James Wong

The moon really may have strange effects on our health

New Scientist - Me, 02/09/2020 - 20:00
Any lunar influence on our health has long been dismissed as unscientific. But new evidence means it may be time to re-evaluate the moon’s subtle effects on our sleep and mental health

Covid-19 news: Steroid drugs save lives in severe coronavirus patients

New Scientist - Me, 02/09/2020 - 19:02
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic

Watch a toy boat float upside down in a levitating puddle

New Scientist - Me, 02/09/2020 - 18:00
By taking advantage of a strange phenomenon in which liquids can be shaken so fast that they levitate, researchers have made a toy boat float upside down

Coronavirus: How to keep children and staff safe when schools reopen

New Scientist - Me, 02/09/2020 - 17:40
Closing schools in response to covid-19 has had a huge impact on children around the world. What we've learned about the coronavirus so far can help us reopen them safely

Coronavirus: Should children returning to school wear face coverings?

New Scientist - Me, 02/09/2020 - 17:40
Advice on whether children should wear face masks to protect against the spread of coronavirus varies around the world and by health body. What does the science say?

Blue jeans pollute water by releasing 50,000 microfibres per wash

New Scientist - Me, 02/09/2020 - 15:00
Around 50,000 microfibres are lost from a pair of jeans in a single wash, and these fibres have been found in large quantities in water across Canada, even in the Arctic

Gravitational wave detectors have found their biggest black hole yet

New Scientist - Me, 02/09/2020 - 15:00
Gravitational wave observatories LIGO and Virgo have spotted their biggest black hole yet at 142 times the mass of the sun, the first hard proof that black holes this size exist

The fuzzy law that could break the idea of a mathematical universe

New Scientist - Me, 02/09/2020 - 14:00
The discovery that a fundamental law of physics cannot be precisely defined challenges the ability of mathematics as we know it to describe reality completely

Sea anemones grow more tentacles when they have plenty of food to eat

New Scientist - Me, 02/09/2020 - 13:59
Animal shape is typically controlled by genes, but sea anemones gain more tentacles if they eat more food – which would be like us growing more arms and legs on a rich diet

Honeybees are able to calculate probability and use it to find food

New Scientist - Me, 02/09/2020 - 02:01
In a lab test, honeybees were able to calculate the probability of an artificial flower dispensing sweetened water, then use this information to inform their foraging strategy

[Articles] Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study

The Lancet - Me, 02/09/2020 - 00:30
Use of liso-cel resulted in a high objective response rate, with a low incidence of grade 3 or worse cytokine release syndrome and neurological events in patients with relapsed or refractory large B-cell lymphomas, including those with diverse histological subtypes and high-risk features. Liso-cel is under further evaluation at first relapse in large B-cell lymphomas and as a treatment for other relapsed or refractory B-cell malignancies.

Gabapentin in pregnancy and the risk of adverse neonatal and maternal outcomes: A population-based cohort study nested in the US Medicaid Analytic eXtract dataset

PLoS Medicine - Ma, 01/09/2020 - 23:00

by Elisabetta Patorno, Sonia Hernandez-Diaz, Krista F. Huybrechts, Rishi J. Desai, Jacqueline M. Cohen, Helen Mogun, Brian T. Bateman

Background

Despite the widespread use, only sparse information is available on the safety of gabapentin during pregnancy. We sought to evaluate the association between gabapentin exposure during pregnancy and risk of adverse neonatal and maternal outcomes.

Methods and findings

Using the United States Medicaid Analytic eXtract (MAX) dataset, we conducted a population-based study of 1,753,865 Medicaid-eligible pregnancies between January 2000 and December 2013. We examined the risk of major congenital malformations and cardiac defects associated with gabapentin exposure during the first trimester (T1), and the risk of preeclampsia (PE), preterm birth (PTB), small for gestational age (SGA), and neonatal intensive care unit admission (NICUa) associated with gabapentin exposure early, late, or both early and late in pregnancy. Gabapentin-unexposed pregnancies served as the reference. We estimated relative risks (RRs) and 95% confidence intervals (CIs) using fine stratification on the propensity score (PS) to control for over 70 confounders (e.g., maternal age, race/ethnicity, indications for gabapentin, other pain conditions, hypertension, diabetes, use of opioids, and specific morphine equivalents). We identified 4,642 pregnancies exposed in T1 (mean age = 28 years; 69% white), 3,745 exposed in early pregnancy only (28 years; 67% white), 556 exposed in late pregnancy only (27 years; 60% white), and 1,275 exposed in both early and late pregnancy (29 years; 75% white). The reference group consisted of 1,744,447 unexposed pregnancies (24 years; 40% white). The adjusted RR for major malformations was 1.07 (95% CI 0.94–1.21, p = 0.33) and for cardiac defects 1.12 (0.89–1.40, p = 0.35). Requiring ≥2 gabapentin dispensings moved the RR to 1.40 (1.03–1.90, p = 0.03) for cardiac defects. There was a higher risk of preterm birth among women exposed to gabapentin either late (RR, 1.28 [1.08–1.52], p < 0.01) or both early and late in pregnancy (RR, 1.22 [1.09–1.36], p < 0.001), SGA among women exposed to gabapentin early (1.17 [1.02–1.33], p = 0.02), late (1.39 [1.01–1.91], p = 0.05), or both early and late in pregnancy (RR, 1.32 [1.08–1.60], p < 0.01), and NICU admission among women exposed to gabapentin both early and late in pregnancy (RR, 1.35 [1.20–1.52], p < 0.001). There was no higher risk of preeclampsia among women exposed to gabapentin after adjustment. Study limitations include the potential for residual confounding and exposure misclassification.

Conclusions

In this large population-based study, we did not find evidence for an association between gabapentin exposure during early pregnancy and major malformations overall, although there was some evidence of a higher risk of cardiac malformations. Maternal use of gabapentin, particularly late in pregnancy, was associated with a higher risk of PTB, SGA, and NICUa.

Human trials of Oxford coronavirus vaccine have begun in the US

New Scientist - Ma, 01/09/2020 - 22:53
The first of 30,000 volunteers in the US have received either a placebo or dose of the Oxford vaccine, to test whether it protects them from coronavirus

Covid-19 news: Millions of pupils return to schools after lockdown

New Scientist - Ma, 01/09/2020 - 19:18
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic

What are T-cells and why have they become a political football?

New Scientist - Ma, 01/09/2020 - 18:47
T-cells are a key part of our immune system, but some say they have been overlooked during the coronavirus pandemic

Science with Sam: Is our reality just one part of a multiverse?

New Scientist - Ma, 01/09/2020 - 18:00
The multiverse is one of the weirdest ideas in science – but it might just be real. Find out how in the second episode of our new video series, Science with Sam
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