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Coronavirus (COVID-19) Update: FDA Authorizes First COVID-19 and Flu Combination Test for use with home-collected samples

Today, the FDA authorized the first diagnostic test for at home collection of patient samples to detect both COVID-19 and influenza A and B (flu).
Categorie: Istituzioni

[Editorial] An African plan to control COVID-19 is urgently needed

The Lancet - %age fa
As governments in countries hit hardest by COVID-19 prepare vaccination programmes against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), other nations face a more uncertain future. In Africa, for example, the pandemic continues to grow, but heterogeneously. Cases are rising sharply in Morocco, Tunisia, Algeria, Libya, Egypt, and South Africa. But in Africa's most populous nation, Nigeria, WHO reports only 1173 deaths from COVID-19. Although data are sparse, the first wave of the pandemic seemed to peak in early August.

[Comment] Seasonal malaria chemoprevention: closing the know–do gap

The Lancet - %age fa
Malaria continues to impact on young lives, causing sickness, impaired school performance, disability, and preventable death, with little progress made to reduce the overall burden since 2014.1,2 In 2019, 274 000, or 67%, of all malaria deaths were in children younger than 5 years in sub-Saharan Africa.2 WHO has recommended seasonal malaria chemoprevention (SMC) for malaria control in areas across the Sahel sub-region since 2012.3 These areas are characterised by a unimodal rainfall pattern, with the majority (at least 60%) of confirmed malaria cases in children younger than 5 years occurring in a short period of not more than 4 consecutive months.

[Comment] Offline: COVID-19—what have we learned so far?

The Lancet - %age fa
COVID-19 has left little time for reflection about lessons to be learned. This coronavirus has provoked us, mobilised us, and distracted us. But with a vaccine on the horizon, it's perhaps time to pause. What have we discovered this past year? And how do these discoveries inform our future? Our annual Lancet–Chinese Academy of Medical Sciences conference—held virtually last week—provided a moment for such contemplation.

[World Report] South Africa and India push for COVID-19 patents ban

The Lancet - %age fa
They want the WTO to temporarily suspend intellectual property rights so that COVID-19 vaccines and other new technologies are accessible for poor countries. Ann Danaiya Usher reports.

[World Report] UN leaders call for key worker recognition for seafarers

The Lancet - %age fa
Seafarers are critical to the pandemic response and their hardships have been ignored. The UN is calling for them to be designated as key workers. John Zarocostas reports.

[World Report] Free period products in Scotland

The Lancet - %age fa
An impassioned campaign to make period products freely available has been won in Scotland in a world first. Jacqui Thornton reports.

[Perspectives] Mona Hanna-Attisha: championing child health against the odds

The Lancet - %age fa
It was mid-morning on March 16, 1988, when, after 2 days of mortar, artillery, and rocket attacks, aircraft returned to hit the people of Halabja, northern Iraq—this time, with an assault of chemical weapons. “I clearly recall, like it was yesterday, I was 11 years old, and my father showed me a picture of this beautiful baby lying on the ground”, says Mona Hanna-Attisha, Associate Professor of Pediatrics and Human Development and CS Mott Endowed Professor of Public Health at Michigan State University in East Lansing, MI, USA.

[Perspectives] Things shameful to be spoken about

The Lancet - %age fa
I'll tell you a secret: the day I graduated from medical school was the happiest day of my life. I was happy on my wedding day, but I threw up as soon as my husband and I arrived at our hotel after the reception—something I've never confided to anyone before. I was happy, too, of course, on the days I gave birth to my children, but that happiness was alloyed with pain and fear. The day I became a doctor I experienced no pain or fear or even gastrointestinal upset—those would come just a few weeks later when I started internship.

[Obituary] Guillermo Soberón

The Lancet - %age fa
Former Mexican Secretary of Health and Rector of UNAM. Born on Dec 29, 1925, in Iguala, Mexico, he died on Oct 12, 2020, of congestive heart failure in Cuernavaca, Mexico, aged 94 years.

[Correspondence] Sepsis

The Lancet - %age fa
Kristina Rudd and colleagues1 used data from more than 100 million individuals to quantify the burden of sepsis. Their alarming findings showed that, despite a decrease in incidence and mortality compared with 1990, 19·7% of global deaths in 2017 were related to sepsis. How many of the 56 million deaths in 2017 could have been preventable if sepsis had been successfully defeated? The proportion of preventable deaths is the essential quantity to draw conclusions on the potential benefit of preventive interventions.

[Correspondence] Sepsis

The Lancet - %age fa
Kristina Rudd and colleagues1 reported the global burden of sepsis incidence and mortality, which has resulted in demanding more effort to be put into reducing its incidence. However, we doubt if the focus on the term sepsis really benefits our patients.

[Correspondence] Sepsis

The Lancet - %age fa
Kristina Rudd and colleagues1 give formidable insights into the distribution and prevalence rates of sepsis globally. We agree that use of administrative data for identification of true rates of sepsis is problematic, “leading to disparate estimates”.1 To this end, we offer three observations and three practical solutions.

[Correspondence] Sepsis

The Lancet - %age fa
We welcome the work of Kristina Rudd and colleagues,1 highlighting the global burden of sepsis that is high in low-income and middle-income countries (LMICs). The burden of sepsis might be reduced with novel digital solutions.

[Correspondence] Sepsis – Authors' reply

The Lancet - %age fa
We thank Maja von Cube and colleagues, Tanca Minderhoud and colleagues, Graeme Duke and colleagues, and Meera Joshi and colleagues for their thoughtful Correspondence regarding our Article1 about the estimation of global, regional, and national sepsis incidence and mortality between 1990 and 2017.

[Correspondence] Freedom from coercion is not discrimination

The Lancet - %age fa
In the World Report about LGBTQ discrimination in US health care,1 the new US Department of Health and Human Services ruling and the Texas federal court ruling from 2019 are inaccurately portrayed. The Christian Medical & Dental Associations (CMDA) was one of the plaintiffs in the case.

[Articles] Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical t

The Lancet - %age fa
Pembrolizumab–chemotherapy showed a significant and clinically meaningful improvement in progression-free survival versus placebo–chemotherapy among patients with metastatic triple-negative breast cancer with CPS of 10 or more. These findings suggest a role for the addition of pembrolizumab to standard chemotherapy for the first-line treatment of metastatic triple-negative breast cancer.

[Articles] Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study

The Lancet - %age fa
SMC at scale was effective in preventing morbidity and mortality from malaria. Serious adverse reactions were rarely reported. Coverage varied, with some areas consistently achieving high levels via door-to-door campaigns. Markers of resistance to sulfadoxine–pyrimethamine and amodiaquine remained uncommon, but with some selection for resistance to sulfadoxine–pyrimethamine, and the situation needs to be carefully monitored. These findings should support efforts to ensure high levels of SMC coverage in west and central Africa.

[Clinical Picture] Primary herpes simplex virus type 2 hepatitis diagnosed during laparoscopy

The Lancet - %age fa
A 31-year-old woman presented to our hospital with a 1-week history of fever, myalgia, and right upper quadrant abdominal pain. She had no significant medical history, history of recent travel, or alcohol use. She reported no genitourinary symptoms, rashes, oral ulcerations, or pharyngitis. She did say that she had been recently sexually active with a new male partner.

[Seminar] Bipolar disorders

The Lancet - %age fa
Bipolar disorders are a complex group of severe and chronic disorders that includes bipolar I disorder, defined by the presence of a syndromal, manic episode, and bipolar II disorder, defined by the presence of a syndromal, hypomanic episode and a major depressive episode. Bipolar disorders substantially reduce psychosocial functioning and are associated with a loss of approximately 10–20 potential years of life. The mortality gap between populations with bipolar disorders and the general population is principally a result of excess deaths from cardiovascular disease and suicide.
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